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How to appraise an article on therapy

Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2QG

^* Correspondence

This first of a series of articles intended to guide clinicians through the evidence-based process assesses the published evidence for drug therapy in Alzheimer's disease. A Medline search identified a randomised, controlled trial of donepezil. Although this trial appeared to have a reasonably sound methodology, we had some doubts about the treatment effect and applicability of the results.