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Optimising neuroleptic treatment for psychotic illness

Dorset Healthcare NHS Trust, King's Park Unit, Gloucester Road, Boscombe, Bournemouth, BH7 6JE

The release of the antipsychotic agents risperidone, sertindole and olanzepine forces difficult choices upon clinicians. The new compounds are better tolerated than neuroleptics, expensive and their long-term side-effects unknown. These choices can be made easier by the dose and side-effect minimisation procedure set out below, which aims to produce the greatest benefit and least harm from conventional neuroleptics.