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Clozapine-induced nocturnal enuresis

diagnostic and treatment issues

GGZ Delfland locatie St Jorisweg 2, 2612 GA, Delft, The Netherlands

AIMS AND METHOD

To report the management of three cases of clozapine-induced enuresis, by description of these cases and literature review.

RESULTS

Heavy sedation, generalised epilepsy and diabetes mellitus induced by clozapine are some of the mechanisms that underlie the emergence of this side-effect.

CLINICAL IMPLICATIONS

These cases illustrate several different pathophysiological mechanisms necessitating further diagnostic investigations before adequate treatment can be started. Clozapine-induced enuresis is probably under-reported owing to the embarrassing nature of this side-effect.