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North Dorset Primary Trust, Forston Clinic, Herrison, Dorchester, Dorset DT2 9TB, e-mail: steve.simpson{at}northdorset-pct.nhs.uk
North Dorset Primary Care Trust
S.S. runs the clinical trials unit in Dorset. However, the present study was not funded by or had any input from any drug company.
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Abstract |
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 Top Abstract IntroductionMethodResultsDiscussionReferences |
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In 2001 the National Institute for Clinical Excellence (NICE) produced guidance for the treatment of Alzheimer’s disease. NICE encourages the withdrawal of medication when the Mini-Mental State Examination (MMSE) score reaches 12 and advises against the treatment of patients with cholinesterase inhibitors if the MMSE score is below 12. Most health authorities have rigorously enforced these guidelines, which has put old age psychiatrists in a difficult position. Our prospective 12 week audit of consecutive patients examines the response to treatment of patients treated both in accordance with and outside of NICE criteria. We also investigated the effect of stopping the medication according to NICE’s recommendation.
RESULTS
Our results suggest that patients outside the NICE criteria respond better than those within the criteria. More disturbingly, when the medication was stopped owing to the MMSE score falling below 12, we found a very high mortality rate (5 out of 25, 20%) or acute deterioration (12 out of 25, 48%). This suggests that the medication is beneficial in the later stages and should not be stopped purely because of the stage of dementia.
CLINICAL IMPLICATIONS
If we are to prevent unnecessary suffering, greater freedom is needed by old age psychiatrists in the use of these antidementia drugs. Patients with severe dementia may benefit from acute treatment. The withdrawal of medication in line with NICE guidance is poor clinical practice and likely to have adverse outcomes in a large proportion of cases.
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Introduction |
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TopAbstractIntroductionMethodResultsDiscussionReferences |
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Method |
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This article describes an audit of 325 consecutive new referrals to the AMS between 2000 and 2004. This was a 12 week prospective audit of acute responses to treatment with cholinesterase inhibitors and a 12 week follow-up after stopping the cholinesterase inhibitors of those patients who had been on them long term but had been withdrawn from treatment on the basis of NICE guidance when the MMSE score fell below 12.
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Results |
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We also looked at the effect of stopping the medication when it was withdrawn on the basis of NICE guidance, i.e. the medication was withdrawn purely because of the stage of the dementia (n=25) rather than intercurrent illness or adherence issues. We followed all patients for 12 weeks after stopping the cholinesterase inhibitors and found that during this short period 17 (68%) had a poor outcome: 5 died and the remaining 12 experienced global deterioration. Overall, 7 (28%) patients displayed no change, with 1 (4%) displaying some level of improvement (Table 2).
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Discussion |
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TopAbstractIntroductionMethodResultsDiscussionReferences |
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This was not a randomised controlled trial and so we cannot conclude that patients with severe dementia should be prioritised, but perhaps clinicians should be allowed to use their clinical judgement more freely in selecting patients for treatment. The original randomised controlled trials included patients with MMSE scores from 10 onwards and more recent trials have been successfully completed on more severe cases of dementia with good response (Tariot et al, 2004). Carer strain and activities of daily living seem to improve the most. The patients treated within the NICE criteria were less disabled. There may be a floor effect in that behavioural complications and carer strain are not as prominent as they are in the later stages of the illness. In simple terms, there may be more scope for improvement in patients with severe dementia. NICE criteria are based on randomised controlled trials of patients who are not likely to be representative of patients referred to old age psychiatry services in day-to-day practice. The AD2000 study (Courtney et al, 2004) found only a modest treatment effect in patients who are consistently within the NICE criteria. In the present study, it is possible that there was an audit sampling bias. Perhaps the consultants were biased in selecting patients outside the NICE criteria on the basis of more prominent behavioural disturbance and the targeting of the most deserving patients and families in their catchment area. Certainly there was benefit, but this was not placebo-controlled. Clearly, more randomised controlled trials are needed to establish how we use cholinesterase inhibitors in severe dementia.
The second main finding was the very poor outcomes when the medicines were stopped because of a low MMSE score. From a qualitative point of view we found great difficulty in getting families to agree to stop the medication. Many described deteriorations, the nature of which did not become completely apparent until the audit findings were looked at more systematically. It is possible that prolonged use of cholinesterase inhibitors leads to changes in receptor activity (Volpicelli-Daley et al, 2003), which results in a rebound deterioration when the treatment is withdrawn. For example, Kemp et al (2003) used single photon emission computed tomography (SPECT) scans with an acetylcholine ligand called QNB and showed that patients on long-term cholinesterase inhibitors have biological changes in post-synaptic muscarinic M1 receptors. Therefore, when cholinesterase inhibitors are stopped there may be receptor changes in addition to simple loss of cholinergic tone attributable to enzyme blockage. Furthermore, there is clinical evidence to suggest that this deterioration is permanent if the medication is not recommenced within 6 weeks of being stopped (Doody et al, 2001).
Other factors might have influenced the death of those with severe dementia. These patients are likely to be the most psychiatrically and physically ill and as such would have had other factors contributing towards their death. Therefore, it is possible that the high death rate reflects a sampling basis. However, this seems less likely because we only audited the 25 outcomes where patients had stopped their medication purely because of NICE guidelines and not because of intercurrent physical illness or adherence issues. Overall, our audit estimates that 68% of patients have adverse outcomes after stopping the medication. This poor outcome included a noticeable mortality, when otherwise at this stage of the illness the life expectancy would be for approximately 2 years to death (Feldman & Gracon, 1996) and not the short 12 weeks that passed during this audit. Certainly, we found that patients did much worse than we had expected on stopping the medication. Clearly, more randomised controlled trials are needed to establish the benefits and disadvantages of stopping cholinesterase inhibitors safely.
Conclusion
The results of our audit were at such variance with what we expected given
the confidence of NICE’s recommendations, that we felt a strong duty of
care to report these findings nationally. The results emphasise the need for
new research on cholinesterase inhibitors in the severe stage of dementia and
on how to change and withdraw medication safely in these patients. More
neurobiological research is needed to determine the long-term effects on
transmitter sensitivities as a result of taking cholinesterase inhibitors.
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References |
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