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Psychiatric Bulletin (2006) 30: 406-409. doi: 10.1192/pb.30.11.406
© 2006 The Royal College of Psychiatrists
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Psychiatric Bulletin (2006) 30: 406-409
© 2006 The Royal College of Psychiatrists

Clinic assessment for methylphenidate maintenance therapy in secondary care: are parental questionnaires useful?

David M. Foreman, Consultant in Child and Adolescent Psychiatry

Skimped Hill Health Centre, Skimped Hill, Bracknell RG12 1LH, email: david_foreman{at}doctors.net.uk and Honorary Senior Lecturer, Maudsley Hospital, Institute of Psychiatry, London

Alexis Beedie

Harris Manchester College, University of Oxford, Oxford OX1 3TD

Ranjit Kapuge, Child and Adolescent Psychiatrist

Rattanapitiya, Borelasgamuwa, Sri Lanka

Declaration of interest

D.M.F. has received £20 000 from Lilly Pharmaceuticals to assess a nurse-led hyperactivity follow-up clinic.


   Abstract
 Top
 Abstract
 Introduction
 Method
 Results
 Discussion
 References
 
AIMS AND METHOD

There is poorer control of hyperactivity symptoms in community clinics than research settings, and difficulty in detecting such symptoms without standardised measures. Hyperkinetic children (n=29) were evaluated at follow-up using the parental version of the Strengths and Difficulties Questionnaire (SDQ) and, independently, routine clinic reports to test the value of a parental questionnaire.

RESULTS

The parental SDQ identified symptoms in more patients (25, 86% v. 13, 45%), but high levels of symptoms did not necessarily imply impairment. Even clinically identified hyperactivity provoked no change in treatment.

CLINICAL IMPLICATIONS

Parental questionnaires alone are unlikely to improve clinic practice. Research is needed into what factors influence clinical decisions regarding treatment maintenance for hyperkinesis, and the adaptation of structured protocols from major research trials should be considered.


   Introduction
 Top
 Abstract
 Introduction
 Method
 Results
 Discussion
 References
 
Hyperactivity is the most common neuropsychiatric disorder of childhood, with prevalence rates for the broader syndrome - attention-deficit hyperactivity disorder (ADHD) - of between 2 and 18% (Rowland et al, 2002) and around 1% for the narrower syndrome of hyperkinesis (Meltzer et al, 2003). Effective treatments are available, but routine community treatment of the disorder is less effective than similar treatments delivered in research protocols (MTA Cooperative Group, 1999). Although there could be several reasons for this, one possibility that has not received attention is that community services might struggle to detect persistent hyperactivity symptoms. It is known that hyperactivity symptoms may be underestimated without the use of screening questionnaires at initial assessment (Foreman et al, 2001), judgements of symptom severity may not relate to diagnostic criteria (Evink et al, 2000) and prescription of stimulants may be better predicted by oppositional/defiant behaviour than hyperactivity itself (Angold et al, 2000). Current guidelines recommend using multiple informants and standardised measures for diagnosis (National Institute for Clinical Excellence, 2000) but there are no recommendations for follow-up assessments, which typically involve a single clinician interviewing the parent and assessing the child in clinic. We therefore compared clinical judgements of continuing hyperactivity with a standardised parental questionnaire on a sample of hyperkinetic children attending a routine community stimulant follow-up clinic. We wished to see whether the clinical use of a standardised measure would be a helpful addition to the routine assessments clinicians already made in follow-up clinics.


   Method
 Top
 Abstract
 Introduction
 Method
 Results
 Discussion
 References
 
Design, service and sample
The study was designed to audit follow-up assessments of children with a diagnosis of hyperactivity attending a secondary care child and adolescent mental health service (CAMHS), serving a population of approximately 90 000, who were prescribed methylphenidate in either conventional or slow-release forms. Questionnaire and routine clinic assessment of continuing hyperactivity were compared. The service diagnosed ICD–10 hyperkinesis (World Health Organization, 1992), rather than ADHD (Taylor et al, 1998) and was provided by two psychiatrists (D.M.F. and R.K.). The audit standards set were that no child reviewed should have significant hyperactivity on either clinic report or the Strengths and Difficulties Questionnaire (SDQ; Goodman, 1999), and there should be no difference between patients of the two psychiatrists. Follow-up assessment was based largely on interview and examination of the parents and child at clinic attendance, with the parents being treated as the main informants about all unobserved aspects of the child’s life. School and other reports or questionnaires were sought only if the clinic assessment or parental accounts were unclear. Figure 1 summarises the exclusion criteria and study attrition.


Figure 1
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Fig. 1. Selection criteria and attrition path. Questionnaires were sent by post with one follow-up telephone call. SDQ, Strengths and Difficulties Questionnaire.

 

Measures
Parents were sent the extended version of the parental SDQ (Goodman, 1999), which is now freely available in several languages (http:/www.sdqinfo.com). We used the UK version for 4- to 16-year-olds, which covered the clinic’s typical age-range. This is a brief screening questionnaire of 25 symptom and 8 impact questions with check-box responses, which provides scale measures for general caseness (total difficulty score), prosocial behaviour, peer relationships, hyperactivity, conduct and emotional problems. Diagnostic algorithms combine symptom and impact scores to provide population-based cut-offs for predictions of three broad diagnostic categories: conduct–oppositional disorder; anxiety–depressive disorder; and hyperactivity–inattention disorder (Goodman et al, 2000). These predictions are rated as ‘unlikely’, ‘possible’ (the top 10-20% of the population) or ‘probable’ (the top 10% of the population) for each diagnosis (Goodman, 2001).

The routine clinical assessment was always summarised in a letter to the referrer that included physical status (weight, height and body mass index), psychiatric symptoms, recommended medication dosage or changes, and change in any psychosocial treatment offered. The letters closest in time prior to (and thus independent of) the SDQ were coded by D.F., who was unaware of the SDQ scores, into hyperactive symptoms being ‘unlikely’, ‘possible’ or ‘probable’, thus generating an ordered category set equivalent to that of the SDQ but reflecting clinical opinion. Mention of overactivity, impulsivity and inattention in the letter was coded as ‘probable’; at least one of these symptoms as ‘possible’; and no mention of any hyperactive symptom was coded as ‘unlikely’. Other information abstracted from the case records is shown in Table 1.


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Table 1. Sample characteristics
 

Analysis
Owing to the small size of the data-set, tabulation and visual displays were used to display important relationships, with non-parametric tests for hypothesis testing.


   Results
 Top
 Abstract
 Introduction
 Method
 Results
 Discussion
 References
 
The questionnaire was sent to 50 families but returned by only 29 (58%); the response probably reflects data collection having to be undertaken during the school summer holidays, which also prevented the concurrent use of the teachers’ version of the SDQ. No difference was found between returners and non-returners on clinic estimate of hyperactivity (Jonckheere–Terpstra test 172, P=0.23).

The sample characteristics are summarised in Table 1; 15 of the children (52%) were seen by D.F., 14 (48%) by R.K. There was no difference between the children for either the clinical (Mann–Whitney U=79, P=0.27) or the SDQ (Mann–Whitney U=86.5, P=0.43) estimates of the probability of the children still being significantly hyperactive. So, this audit standard was met.

The audit standard that no child should have significant continuing hyperactivity was not met using either criterion, and the overall agreement between them, although significant, was poor (Table 2): 25 (86%) children were symptomatic by the SDQ, 13 (45%) by clinical opinion. No other variable predicted the clinicians’ estimate of symptoms. No child had their medication or psychosocial treatment changed at the clinic appointment referred to in the letter.


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Table 2. Association between questionnaire and clinic assessments of continuing hyperactivity1
 

Fifteen children (52%) had a maximum score on the SDQ hyperactivity sub-scale. Although numerical analysis suggested an overall association between the SDQ measure of impairment–impact and this sub-scale (Spearman’s rho=0.436, P=0.009), Fig. 2 shows that this relationship broke down at higher hyperactivity sub-scale scores, as did the relationship between the hyperactivity sub-scale, the SDQ total difficulty score and clinical opinion.


Figure 2
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Fig. 2. Hyperactivity v. impairment scores on the Strengths and Difficulties Questionnaire (SDQ). Clinical opinion of presence of continuing hyperactivity: {circ}, unlikely; {square}, possible; X, probable.

 

   Discussion
 Top
 Abstract
 Introduction
 Method
 Results
 Discussion
 References
 
A substantial proportion of young people attending an ordinary hyperactivity medication follow-up clinic have continuing problems with hyperactivity, despite having been in treatment for, on average, more than 3 years. The SDQ detected more hyperactive symptoms than the clinic letters indicated. However, high SDQ scores for hyperactive symptoms had little association with SDQ estimates of total difficulty or impairment. So, although parental SDQ can demonstrate imperfections in the detection of hyperactive symptoms in ordinary clinic assessment, its routine adjunctive use could further confuse, rather than improve, assessment at follow-up, as the differing scores do not afford a simple interpretation. Although a range of physical and psychological treatments are used (Table 1) no child’s treatment was changed, despite continuing hyperactive symptoms being identified clinically in nearly half. Clinicians may be considering the risk of side-effects, or they may be benchmarking current symptoms and impairment against greater past difficulty, neither of which this study measured.

The chief limitations of the study are the small sample size, the risk of selection bias, and the children being from a single, secondary care psychiatric clinic. Despite all this, including the inevitable confounding of general with local characteristics of staff and patients, the sample characteristics, symptoms and treatment profiles are typical of hyperactive children seen and treated in secondary care (Coffey, 1997; Swanson et al, 2001). The study did not include children with non-hyperkinetic ADHD or children managed in primary care alone. It is likely that hyperactivity will be harder to detect in the broader syndrome of ADHD, and that more general services will have less skill and experience than dedicated secondary care provision, so the difficulties identified here may be more apparent in settings using the broader diagnosis and fewer specialist staff. The study did not separately consider other factors affecting treatment decisions, such as perceived risks of side-effects, parental preferences over drug dosage or current availability of psychological treatments, so it cannot be inferred that the clinicians’ decisions not to modify treatment in the presence of hyperactive symptoms are irrational.

As was suspected, even alert clinicians do struggle to detect continuing hyperactivity in follow-up clinics. The SDQ results suggest that simply adding a questionnaire to be completed by parents at follow-up will identify more symptoms, but its clinical significance will be uncertain. Given the small sample size and the single centre of the present study, larger confirmatory studies in multiple centres are needed. It seems unlikely that another questionnaire would have produced different results: most questionnaires seem similar in their abilities to detect hyperactivity (Collett et al, 2003), and there seems little to choose between more general and more specific questionnaires (Foreman et al 2001). It might seem prudent to ensure that follow-up assessment includes additional data to those provided by the parents and clinic observation (e.g. first-hand reports or observations from the school). However, following such recommendations would require limiting follow-up clinics to the school terms, and making prior arrangements to obtain school-based reports or questionnaires. Both these changes would present considerable logistical problems and might not change clinicians’ behaviour, as even the clinical identification of continuing hyperactive symptoms does not necessarily lead to a change in treatment. Further research is needed to clarify the factors influencing clinicians’ treatment decisions: for example, clinical detection of side-effects and impairment was not assessed in this study. Structured treatment protocols that limit clinical judgement, as used in research trials, might produce better outcomes. This goes beyond current clinical guidelines (American Academy of Pediatrics, 2001; National Institute for Clinical Excellence, 2000) but is consistent with research. However, it would need testing by appropriate studies.


   References
 Top
 Abstract
 Introduction
 Method
 Results
 Discussion
 References
 
AMERICAN ACADEMY OF PEDIATRICS (2001) Clinical practice guideline: treatment of the school-age child with attention-deficit hyperactivity disorder. Pediatrics, 108, 1033 –1044.[Abstract/Free Full Text]

ANGOLD, A., ERKANLI, A., EGGER, H. L. et al (2000) Stimulant treatment for children: a community perspective. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 975 –984.[CrossRef][Medline]

COFFEY, B. (1997) Attention deficit hyperactivity disorder. In Handbook of Child and Adolescent Psychiatry (eds. P. Kernberg & J. Bemporad), pp. 456 –483. New York: Wiley.

COLLETT, B., OHAN, J. & MYERS, K. M. (2003) Ten-year review of rating scales. V. Scales assessing attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 1015 –1037.[CrossRef][Medline]

EVINK, B., CROUSE, B. J. & ELLIOTT, B. A. (2000) Diagnosing childhood attention-deficit/hyperactivity "strong"disorder. Do family practitioners and pediatricians make the same call? Minnesota Medicine, 83, 57 –62.[Medline]

FOREMAN, D., FOREMAN, D., PRENDERGAST, M., et al (2001) Is clinic prevalence of ICD–10 hyperkinesis underestimated? Impact of increasing awareness by a questionnaire. European Child and Adolescent Psychiatry, 10, 130 –134.[CrossRef][Medline]

GOODMAN, R. (1999) The extended version of the Strengths and Difficulties Questionnaire as a guide to child psychiatric caseness and consequent burden. Journal of Child Psychology and Psychiatry and Allied Disciplines, 40, 791 –799.[CrossRef][Medline]

GOODMAN, R. (2001) Psychometric properties of the strengths and difficulties questionnaire. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 1337 –1345.[CrossRef][Medline]

GOODMAN, R., RENFREW, D. & MULLICK, M. (2000) Predicting type of psychiatric disorder from Strengths and Difficulties Questionnaire (SDQ) scores in child mental health clinics in London and Dhaka. European Child and Adolescent Psychiatry, 9, 129 –134.[CrossRef][Medline]

MELTZER, H., GATWARD, R., GOODMAN, R., et al (2003) Mental health of children and adolescents in Great Britain. International Review of Psychiatry, 15, 185 –187.[CrossRef][Medline]

MTA COOPERATIVE GROUP (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 56, 1073 –1086.[Abstract/Free Full Text]

NATIONAL INSTITUTE FOR CLINICAL EXCELLENCE (2000) Guidance on the Treatment of ADHD. London: NICE.

ROWLAND, A. S., LESESNE, C. A. & ABRAMOWITZ, A. J. (2002) The epidemiology of attention-deficit hyperactivity disorder (ADHD): a public health view. Mental Retardation and Developmental Disabilities Research Reviews, 8, 162 –170.[CrossRef][Medline]

SWANSON, J., KRAEMER, H., HINSHAW, S., et al (2001) Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 168 –179.[CrossRef][Medline]

TAYLOR, E., SERGEANT, J., DOEPFNER, M., et al (1998) Clinical guidelines of hyperkinetic disorder. European society for child and adolescent psychiatry. European Child and Adolescent Psychiatry, 7, 184 –200.[CrossRef][Medline]

WORLD HEALTH ORGANIZATION (1992) Tenth Revision of the International Classification of Diseases and Related Health Problems (ICD 10). Geneva: WHO.





This Article
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Right arrow Articles by Foreman, D. M.
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