Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-17T16:29:10.816Z Has data issue: false hasContentIssue false

Antidepressants and murder

Published online by Cambridge University Press:  02 January 2018

J. Guy Edwards*
Affiliation:
Royal South Hants Hospital, Southampton SO9 4PE
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A 44-year-old man was treated with amitriptyline by his general practitioner for ‘mild depression’. Shortly after starting treatment he was said to have become ‘beserk’; he hit his wife and a family friend with an iron bar and attempted to sever their heads with a kitchen knife. He was found guilty of manslaughter on the grounds of substantially diminished responsibility and sentenced to life imprisonment.

Type
Expert opinion
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © Royal College of Psychiatrists, 1992

References

Angst, J. (1987) Switch from depression to mania, or from mania to depression. Journal of Psychopharmacology, 1, 1319.CrossRefGoogle ScholarPubMed
Bond, A. & Lader, M. (1979) Benzodiazepines and aggression. In Psychopharmacology of Aggression (ed. Sandler, M.) New York: Raven Press, pp. 173182.Google Scholar
Coryell, W. & Winokur, G. (1982) Course and outcome. In Handbook of Affective Disorders (ed. by Paykel, E. S.) Edinburgh: Churchill Livingstone, pp. 93106.Google Scholar
Delini-Stula, A. & Vassort, A. (1979) Differential effects of psychoactive drugs on aggressive responses in mice and rats. In Psychopharmacology of Aggression (ed. Sandler, M.). New York: Raven Press, pp. 4160 Google Scholar
Dyer, C. (1991) Murder on antidepressants. British Medical Journal. 303, 331332.Google Scholar
Edwards, J. G. (1981) Unwanted effects of psychotropic drugs and their mechanisms. In Handbook of Biological Psychiatry. Part VI. Practical Application of Psychotropic Drugs and other Biological Treatmentsv (eds. van Praag, H. M., Lader, M. H., Raphaelson, O. J. & Sachar, E. J.). New York: Marcel Dekker, pp. 138.Google Scholar
Lewis, J. L. & Winokur, G. (1982) The induction of mania. A natural history study with controls. Archives of General Psychiatry, 39, 303306.Google Scholar
Rampling, D. (1978) Aggression: A paradoxical response to tricyclic antidepressants. American Journal of Psychiatry, 135, 117118.Google ScholarPubMed
Schader, R. I., Dimascio, A. & Associates (1977) Psychotropic Drug Side Effects. Clinical and Theoretical Perspectives. Huntington, New York: Robert E. Krieber.Google Scholar
Soloman, R. L., Rich, C. L. & Darko, D. F. (1990) Antidepressant treatment and the occurrence of mania in bipolar patients admitted for depression. Journal of Affective Disorders, 18, 253257.Google Scholar
Sugarman, P. & Hughes, T. (1991) Assault after ingestion of antidepressant British Medical Journal, 303, 720.Google Scholar
Waring, E. M. (1977) Unusual therapeutic effect of amitriptyline. Canadian Medical Association Journal, 117, 21.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.