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Anti-N-methyl-d-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment

Published online by Cambridge University Press:  02 January 2018

Helen Barry*
Affiliation:
Royal College of Surgeons in Ireland, Dublin, Ireland
Susan Byrne
Affiliation:
Trinity College, Dublin
Elizabeth Barrett
Affiliation:
Temple Street Children's University Hospital, Dublin
Kieran C. Murphy
Affiliation:
Royal College of Surgeons in Ireland, Dublin, Ireland
David R. Cotter
Affiliation:
Royal College of Surgeons in Ireland, Dublin, Ireland
*
Correspondence to Helen Barry (helenbarry@rcsi.ie)
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Summary

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a form of encephalitis occurring primarily in women and associated with antibodies against NR1 or NR2 subunits of the NMDA receptor. As a potentially treatable differential for symptoms and signs seen in neurology and psychiatric clinics, clinicians practising across the lifespan should be aware of this form of encephalitis. Common clinical features include auditory and visual hallucinations, delusions, behavioural change (frequently with agitation), impaired consciousness, motor disturbance (ranging from dyskinesia to catatonia), seizures, and autonomic dysfunction. We present a review of the literature on the disorder, including its clinical presentation, differential diagnosis, epidemiology, treatment and prognosis.

Type
Review Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an open-access article published by the Royal College of Psychiatrists and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © 2014 The Authors

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis was first described in 2007 by Dalmau and colleagues, Reference Dalmau and Bataller1 who identified 12 patients presenting with prominent neuropsychiatric symptoms. All were confirmed to have serum or cerebrospinal fluid (CSF) antibodies to the NMDA receptor. Reference Dalmau and Bataller1 In a subsequent case series of 100 patients, 77 initially presented to psychiatric services. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 Although patients with anti-NMDA receptor encephalitis exhibit high rates of psychiatric disorder, psychiatrists may not be fully aware of the diverse presentation of this disorder. Given the high mortality rate (up to 25%), the likelihood of presentation across the age range and the potential for treatment, a high index of suspicion is warranted by clinicians.

Epidemiology

Epidemiological studies suggest that anti-NMDA receptor encephalitis may be the most common cause of autoimmune encephalitis after acute demyelinating encephalitis. Reference Granerod, Ambrose, Davies, Clewley, Walsh and Morgan3 While to date there are no estimates as to prevalence rates, more than 500 cases have been reported. Reference Titulaer, McCracken, Gabilondo, Armangue, Glaser and Iizuka4Reference Dalmau, Lancaster, Martinez-Hernandez, Rosenfeld and Balice-Gordon6 Between September 2007 and February 2011, the California Encephalitis Project examined referrals of 761 patients presenting with encephalitis. Reference Gable, Sheriff, Dalmau, Tilley and Glaser7 Of the cases of identified aetiology, anti-NMDA receptor encephalitis was the leading entity (32 of 79 cases) within the cohort and was identified four times as frequently as herpes simplex – type 1, West Nile virus or varicella zoster virus. Reference Gable, Sheriff, Dalmau, Tilley and Glaser7 In another study, Steiner and colleagues examined 121 individuals with schizophrenia for diverse NMDA receptor antibodies. Approximately 10% (n = 15) were found to be positive for anti-NMDA receptor antibodies, two of whom had the specific immunoglobulin G (IgG) NR1a antibodies of anti-NMDA receptor encephalitis. Reference Steiner, Walter, Glanz, Sarnyai, Bernstein and Vielhaber8 Zandi et al Reference Zandi, Irani, Lang, Waters, Jones and McKenna9 observed NMDA receptor serum antibodies in approximately 6% (3 of 46) of patients with first-onset schizophrenia. The true rate of anti-NMDA receptor encephalitis in the population generally and among individuals with psychosis is thus not yet fully clarified.

Pathophysiology

Encephalitis and psychosis have a long association, with a viral aetiology of psychosis hypothesised as early as the 19th century. The influenza epidemic in the early 20th century led Karl Menninger to conclude that ‘dementia praecox is at least in most instances a somatopsychosis, the psychic manifestations of an Encephalitis’. Reference Menninger10 While the dopaminergic model of schizophrenia has been the leading neurochemical hypothesis of psychosis for many decades, hypofunction of the NMDA-type glutamate receptors provides an alternative model to understanding the pathogenesis of schizophrenia. It is well described that antagonists of NMDA receptors (e.g. phencyclidine (PCP)) produce a clinical syndrome that closely resembles negative symptoms of schizophrenia and induce neuropsychological and sensory processing deficits that are very similar to those observed in schizophrenia. Reference Baldridge and Bessen11

The prominent psychotic symptoms, catatonia and indicators of dopaminergic involvement (orofacial dyskinesias) are all consistent with the effects of PCP, Reference Baldridge and Bessen11 which is well recognised to also replicate many aspects of the presentation of schizophrenia. NMDA receptor antagonists are believed to function by blocking the NMDA receptor in the presynaptic gamma-aminobutyric acid (GABA)-ergic neurons of the thalamus and frontal cortex, leading to a disinhibition of postsynaptic glutamatergic neurons and subsequent glutamatergic and dopaminergic dysregulation in the frontal cortex.

It has been observed that nitroprusside completely abolishes the behavioural effects of PCP in animal models. Reference Bujas-Bobanovic, Bird, Robertson and Dursun12 Hallak and colleagues Reference Hallak, Maia-de-Oliveira, Abrao, Evora, Zuardi and Crippa13 administered a sodium nitroprusside infusion to 20 patients with a diagnosis of schizophrenia, with a resultant rapid improvement in symptoms. They hypothesise that in addition to generating nitric oxide in the brain and increasing cAMP production, nitroprusside may also modulate NMDA receptor activity. In addition, reductions in plasma and brain glycine, D-serine and glutathione levels provide additional mechanisms underlying NMDA dysfunction. Reference Kantrowitz and Javitt14

The neuropsychiatric presentation of these cases of anti-NMDA receptor encephalitis thus provides important support for the NMDA receptor hypofunction hypothesis for psychosis. Reference Tsai, Yang, Chung, Lange and Coyle15,Reference Stone, Morrison and Pilowsky16 Explanations for the proposed NMDA receptor hypofunction in schizophrenia are varied and may involve altered recycling of NMDA receptors. Reference Lisman, Coyle, Green, Javitt, Benes and Heckers17 However, the possibility that autoantibodies to the NMDA receptor subunits may be causal in psychotic presentations is novel.

Acute psychosis in anti-NMDA receptor encephalitis is associated with serum and CSF IgG antibody titres against the NR1a subunit of the receptor. However, antibodies against different antigens (e.g. the NR2a and NR2b subunits) have been described in cases of limbic encephalitis and systematic lupus erthymatosus, Reference Arinuma, Yanagida and Hirohata18,Reference Mochizuki, Mizutani, Isozaki, Ohtake and Takahashi19 and psychiatric symptoms may not be exclusive to the NR1a subunit. Steiner et al Reference Steiner, Walter, Glanz, Sarnyai, Bernstein and Vielhaber8 examined the serum of 459 patients admitted with schizophrenia (n = 121), major depression (n = 70) and borderline personality disorder (n = 38) for a variety of antibody subtypes in order to determine whether antibody subtypes overlap with or are distinct from those in anti-NMDA receptor encephalitis. They identified NMDA antibodies in 9.9% of patients with schizophrenia. Diverse NMDA receptor antibodies, including those specifically found in anti-NMDA receptor encephalitis, were found primarily in those with an initial diagnosis of schizophrenia; two patients initially diagnosed with a disorganised or catatonic schizophrenia were subsequently diagnosed with, and treated for, anti-NMDA receptor encephalitis. Reference Steiner, Walter, Glanz, Sarnyai, Bernstein and Vielhaber8

Potential causes for the behaviour, learning and memory difficulties in anti-NMDA receptor encephalitis have been postulated by Iizuka and colleagues, Reference Iizuka, Sakai, Ide, Monzen, Yoshii and Iigaya20 who noted reversible predominant frontotemporal atrophy, an area in which NMDA receptors are present in high density, therefore suggestive of an immunological cause to the atrophy.

Anti-NMDA receptor encephalitis is associated in some cases with ovarian pathology, in particular teratomas. It is considered that the antibodies to the NR1–NR2 subunits of the NMDA subtype of glutamate receptors develop in response to this abnormal tissue.

Clinical presentation

Presentations can be variable, thus posing a challenge to clinicians in neurology and psychiatry settings. With symptoms and signs ranging from psychosis to mania to catatonia, clinicians may be prompted to consider primary mental health aetiology. Dalmau et al Reference Dalmau, Lancaster, Martinez-Hernandez, Rosenfeld and Balice-Gordon6 have proposed a staged presentation. Maneta et al Reference Maneta and Garcia5 summarise these into early, middle and late symptoms, initially involving a prodrome, followed by more overt psychiatric manifestations and later physical symptoms.

Clinicians should be aware that the presentation of anti-NMDA receptor encephalitis includes several characteristic features.

  1. (a) A non-specific prodrome: in one series of 100 individuals with encephalitis, 86% had headache, low-grade fever or a viral-like illness (headaches, respiratory or gastrointestinal symptoms) in the weeks prior to acute presentation. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 In our series of five cases, we identified a prodrome in four, with symptoms including poor concentration, anorexia, insomnia and slurred speech. Reference Dalmau, Lancaster, Martinez-Hernandez, Rosenfeld and Balice-Gordon6

  2. (b) Psychiatric symptoms are prominent: agitation, bizarre and disinhibited behaviour, delusions and auditory and visual hallucinations. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 In our series, the psychotic phenomena observed were markedly fragmented in comparison with those typically found in functional psychoses, with delusions being poorly formed and non-systematised. Reference Dalmau, Lancaster, Martinez-Hernandez, Rosenfeld and Balice-Gordon6

  3. (c) Cognitive dysfunction: short-term memory loss can also be a presenting feature, as can concentration difficulties. Formal neuropsychological testing in the presence of psychosis and/or behavioural disturbance may present difficulties in clinical practice.

  4. (d) Motor dysfunction: in addition to typical epileptic seizures, patients often develop dyskinetic movements, including orofacial dyskinesias (grimacing or lip smacking), which may be mistaken for seizures. These abnormal movements, especially orofacial dyskinesia, may present from an early stage and are often a clue to the diagnosis.

  5. (e) Autonomic instability: autonomic instability and hypoventilation can also occur (41 of Dalmau’s series Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 had one or both of these features), as can cardiac dysrhythmias often necessitating intensive care unit management. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 Dissociative responses to stimuli during have been noted, including resistance to eye opening while displaying no response to painful stimuli, a combination that may lead to diagnostic confusion. Reference Iizuka, Sakai, Ide, Monzen, Yoshii and Iigaya20,Reference Gonzalez-Valcarcel, Rosenfeld and Dalmau21

  6. (f) Association with known pathology: an association with ovarian pathology has also been identified. Dalmau and colleagues reported that in 59% of cases, the diagnosis was associated with ovarian tumours, primarily ovarian teratomas. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 However, Irani and colleagues identified tumours in only 26% (9 of 34) of cases. Reference Irani, Bera, Waters, Zuliani, Maxwell and Zandi22 Children under the age of 18 are unlikely to have an associated tumour.

Diagnosis

Confirmation of the clinical diagnosis of anti-NMDA receptor encephalitis requires a positive serum or CSF sample screening for antibodies to the NMDA receptor subunit. There is ongoing controversy as to whether serum or CSF is best tested. Dalmau recommends testing of both, Reference Dalmau, Lancaster, Martinez-Hernandez, Rosenfeld and Balice-Gordon6 whereas Irani & Vincent, Reference Irani and Vincent23 by contrast, report that serum levels of anti-NMDA receptor antibodies were similar or higher to those of CSF. The clinical symptoms of this disorder correlate well with antibody titre. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 The test for anti-NMDA receptor encephalitis, although currently somewhat slow, is relatively cheap, and therefore should be considered in any patient presenting with an acute onset of psychiatric symptoms with atypical features or unusual movements.

CSF abnormalities have been described in approximately 80% of cases and include a mild lymphocyctic pleocytosis, normally or mildly increased protein concentration, and CSF-specific oligoclonal bands. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2,Reference Barry, Hardiman, Healy, Keogan, Moroney and Molnar24

Brain magnetic resonance imaging scans have been reported as normal in 70% of cases. Reference Titulaer, McCracken, Gabilondo, Armangue, Glaser and Iizuka4 In the remainder, hyperintensities in a variety of regions may be evident (implicated areas include the hippocampi, cerebellar and cerebral cortex, basal ganglia, brainstem, frontobasal and insular regions). Reference Dalmau, Tuzun, Wu, Masjuan, Rossi and Voloschin25

Typically, electroencephalograms (EEGs) may show non-specific slowing or slow continuous rhythmic activity during the catatonic phase of illness. Reference Florance, Davis, Lam, Szperka, Zhou and Ahmad26 An EEG is very helpful if one is trying to distinguish between encephalitis and a primary psychiatric disorder, as the majority of patients (90%) with anti-NMDA receptor encephalitis have evidence of non-specific slowing at some stage during the illness. Reference Titulaer, McCracken, Gabilondo, Armangue, Glaser and Iizuka4

While not at present likely to support clinical practice, other investigations have been reviewed. Positron emission tomography has shown variable findings, with some evidence of cortical hypometabolism. Reference Pillai, Gill, Webster, Howman-Giles and Dale27 This contrasts with findings from other investigators, suggesting subcortical hypermetabolism. Reference Maeder-Ingvar, Prior, Irani, Rey, Vincent and Rossetti28

Differential diagnosis

The condition may present in the domain of either the neurologist or the psychiatrist, depending on whether psychiatric symptoms precede the neurological features, as is often the case.

Neurological

Neurological differential diagnosis tends to include viral encephalitis, cerebral vasculitis or other forms of autoimmune encephalitis and encephalitis lethargica. Reference Dale, Irani, Brilot, Pillai, Webster and Gill29 Dyskinetic movements may be mistaken for seizure activity or tardive dyskinesia. Patients can also have bizarre stereotypies. Repetitive stereotypies and orofacial dyskinesia can be mistaken for seizures. Reference Dericioglu, Vural, Acar, Agayeva, Ismailova and Kurne30 The seizure-like dyskinetic movements may also be misdiagnosed as status epilepticus, a diagnosis that is reported in 6% of cases. Reference Dericioglu, Vural, Acar, Agayeva, Ismailova and Kurne30 Dericioglu and colleagues Reference Dericioglu, Vural, Acar, Agayeva, Ismailova and Kurne30 report two cases where status epilepticus was suspected but video EEG was indicative of encephalopathy, thus avoiding aggressive treatment with intravenous anaesthetics. Caution therefore is advised in interpreting these movements, unless clarified by video EEG, when status epilepticus is suspected. Reference Dericioglu, Vural, Acar, Agayeva, Ismailova and Kurne30

Psychiatric

Psychiatric differential diagnoses are usually the primary differential in the initial phase of illness. New-onset psychosis is typically recorded in the literature as the most common initial diagnosis because of the presence of delusions, hallucinations and catatonic features. Recent studies explore the possibility that this disorder, or indeed other similar autoimmune conditions, may present with a more typical schizophrenia picture and be responsible for as much as 5–10% of first-onset psychosis. Reference Steiner, Walter, Glanz, Sarnyai, Bernstein and Vielhaber8,Reference Zandi, Irani, Lang, Waters, Jones and McKenna9 Zandi and colleagues Reference Zandi, Irani, Lang, Waters, Jones and McKenna9 screened a 46-patient cohort of first-episode psychosis patients in a prospective study for NMDA receptor antibodies and only 2 tested positive. The authors state that there were no clinical features to differentiate these individuals from other individuals with psychosis in the cohort.

Cases of ‘postnatal psychosis’ in association with ovarian pathology that bear remarkable similarity to anti-NMDA receptor encephalitis have also been described. Reference Hopker and Brockington31

The presence of rigidity and altered consciousness, which are common in anti-NMDA receptor encephalitis, may also lead to consideration of a diagnosis of neuroleptic malignant syndrome, particularly when antipsychotic medications are prescribed. This may present both a diagnostic dilemma and a management challenge in clinical practice, as these diagnoses are clearly not mutually exclusive.

Treatment options

It is important to note that treatment must target both the cause and the clinical consequences of the encephalitis (the behavioural and psychotic symptoms). With respect to the former, first-line treatment is immunotherapy, typically corticosteroids, intravenous immunoglobulins or plasma exchange, in addition to the removal of any identified teratomas. Titres are effectively reduced by immunomodulatory treatments, including high-dose steroids, intravenous gamma globulin and plasmaphoresis.

Behavioural disturbance can be a marked obstacle to initiation of treatment, often requiring patients to be sedated for administration of plasma exchange.

Second-line immunosuppression may be necessary using rituximab or cyclophosphamide.

These are often required in individuals who receive a delayed diagnosis or those without a tumour. Reference Florance, Davis, Lam, Szperka, Zhou and Ahmad26 Liba et al Reference Liba, Sebronova, Komarek, Sediva and Sedlacek32 report use of alemtuzumab in an 8-year-old child with a positive outcome.

Treatment is generally thought to be more effective in patients who have an underlying tumour removed. Cases of ovarian teratomas discovered years after initial onset of symptoms have been described, particularly in patients who experienced a slow recovery. Reference Iizuka, Sakai, Ide, Monzen, Yoshii and Iigaya20 Peery and colleagues describe a case where oophorectomy was performed despite negative scan results and on postoperative biopsy an occult teratoma was revealed, with subsequent improvement in clinical symptoms. Reference Peery, Day, Doja, Xia, Fritzler and Foster33

With respect to the immediate management of behavioural and psychotic symptoms, both typical and atypical, antipsychotics have been utilised. It must be noted that use of antipsychotics can complicate the picture, particularly prior to definite antibody diagnosis. The development of autonomic instability and rigidity may be mistaken for neuroleptic malignant syndrome. In addition, use of corticosteroids may result in confusion with a steroid-induced psychosis. Clonidine, trazadone and benzodiazepines have been used successfully for reversal of sleep disturbance. Reference Chapman and Vause34

Catatonic symptoms are typically treated with benzodiazepine medication. Doses of up to 20–30 mg of lorazepam daily have been used to manage symptoms in catatonia, although little has been published on its efficacy in anti-NMDA receptor encephalitis. Reference Fink and Taylor35 Electroconvulsive therapy (ECT), though the gold standard for treatment of catatonia in the absence of a response to benzodiazepines, is little studied in the area of anti-NMDA receptor encephalitis. Case reports of catatonic symptom response in anti-NMDA receptor encephalitis have been described. Reference Braakman, Moers-Hornikx, Arts, Hupperts and Nicolai36 Interestingly, in animal models of ECT action, an elevation of messenger ribonucleic acid (mRNA) of the NMDA subunits NR2A and NR2B has been demonstrated, leading to an up-regulation of the NMDA receptor. Reference Watkins, Pei and Newberry37

Prognosis

According to Dalmau’s original case series, approximately 75% of patients with NMDA receptor antibodies recover or have mild sequelae; the other 25% have severe deficits or die. Reference Dalmau, Gleichman, Hughes, Rossi, Peng and Lai2 Subsequent studies have identified a 12–24% risk of relapse. Reference Zandi, Irani, Lang, Waters, Jones and McKenna9,Reference Chapman and Vause34,Reference Fink and Taylor35 Mortality of 7% at 24 months has been noted. Reference Titulaer, McCracken, Gabilondo, Armangue, Glaser and Iizuka4 Other studies have noted that approximately 25% of patients at diagnosis give a history of one or more similar symptom episodes in the months preceding diagnosis, indicating a more relapsing and remitting course of illness than initially described. Reference Florance, Davis, Lam, Szperka, Zhou and Ahmad26

Titulaer et al Reference Titulaer, McCracken, Gabilondo, Armangue, Glaser and Iizuka4 in a cohort study of 577 patients noted that first-line immunotherapy resulted in an improvement in 53% of patients in the first 4 weeks of treatment, 97% of whom showed a good outcome at 24 months. In the 47% of patients who did not respond to first-line treatment, those who received second-line immunotherapy (i.e. rituximab, cyclophosphamide or both) had better outcomes than those who continued first-line treatment or received no further immunotherapy. Reference Titulaer, McCracken, Gabilondo, Armangue, Glaser and Iizuka4

Several prognostic factors are implicated. With respect to duration of illness and treatment outcome, Finke and colleagues Reference Finke, Kopp, Pruss, Dalmau, Wandinger and Ploner38 demonstrated a better cognitive outcome in a small cohort of adult patients with anti-NMDA receptor encephalitis who were treated with immunomodulatory therapy within 3 months of disease’s onset compared with those who were treated at a later stage or not at all. The authors proposed that a delay in treatment may lead to permanent hippocampal damage, Reference Finke, Kopp, Pruss, Dalmau, Wandinger and Ploner38 yet the optimal time frame from onset of symptoms to treatment has yet to be determined.

Other identified predictors of outcome include: lower severity of symptoms, not requiring ICU admission, prompt initiation of immunotherapy and tumour removal where present. Reference Titulaer, McCracken, Gabilondo, Armangue, Glaser and Iizuka4,Reference Irani, Bera, Waters, Zuliani, Maxwell and Zandi39

Summary and implications to clinical practice

Anti-NMDA receptor encephalitis is a relatively newly identified and potentially treatable cause of psychiatric symptoms in both adults and children. Several hundred cases have been reported since its identification in 2007; however, clinicians may be unaware of developments in this field. It is vital for psychiatrists working across the age spectrum to be aware of this condition and to engage in timely liaison with our neurology colleagues, thus facilitating early screening and diagnosis.

There are a wide range of presenting symptoms and signs. Patients may present with prodromal features, followed by psychiatric and perhaps later physical manifestations. As outlined, anti-NMDA receptor encephalitis is easily diagnosed using a blood or CSF test. This presents the opportunity for early treatment, and a low index of suspicion should be considered for any patient presenting with a constellation of symptoms.

To date, the recommendation for screening has advised testing of those patients, particularly females, with an atypical new-onset presentation of psychosis with motor features. However, recent studies have questioned how readily this disorder is distinguishable from those where patients receive a purely psychiatric psychotic diagnosis.

It is clear that early identification and treatment may have serious prognostic implications. Delay to treatment with immunosuppressive therapy probably results in worsened outcomes, with evidence for permanent hippocampal damage. Reference Finke, Kopp, Pruss, Dalmau, Wandinger and Ploner38 Management may prove clinically challenging, from the perspective of treating both the cause and the symptoms. Initiation of antipsychotic treatment is not without risk in these patients and behavioural management may prove challenging.

Anti-NMDA receptor encephalitis is a potentially treatable form of psychiatric illness that is illuminating our understanding of the neuropathophysiology involved in some individuals who present with symptoms of psychosis.

Footnotes

Declaration of interest

None.

References

1 Dalmau, J, Bataller, L. Limbic encephalitis: the new cell membrane antigens and a proposal of clinical-immunological classification with therapeutic implications. Neurologia 2007; 22: 526–37.Google Scholar
2 Dalmau, J, Gleichman, AJ, Hughes, EG, Rossi, JE, Peng, X, Lai, M, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7: 1091–8.CrossRefGoogle ScholarPubMed
3 Granerod, J, Ambrose, HE, Davies, NW, Clewley, JP, Walsh, AL, Morgan, D, et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis 2010; 10: 835–44.CrossRefGoogle Scholar
4 Titulaer, MJ, McCracken, L, Gabilondo, I, Armangue, T, Glaser, C, Iizuka, T, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 2013; 12: 157–65.CrossRefGoogle ScholarPubMed
5 Maneta, E, Garcia, G. Psychiatric manifestations of anti-NMDA receptor encephalitis: neurobiological underpinnings and differential diagnostic implications. Psychosomatics 2014; 55: 3744.CrossRefGoogle ScholarPubMed
6 Dalmau, J, Lancaster, E, Martinez-Hernandez, E, Rosenfeld, MR, Balice-Gordon, R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 2011; 10: 6374.CrossRefGoogle ScholarPubMed
7 Gable, MS, Sheriff, H, Dalmau, J, Tilley, DH, Glaser, CA. The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis 2012; 54: 899904.CrossRefGoogle ScholarPubMed
8 Steiner, J, Walter, M, Glanz, W, Sarnyai, Z, Bernstein, HG, Vielhaber, S, et al. Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry 2013; 70: 271–8.CrossRefGoogle ScholarPubMed
9 Zandi, MS, Irani, SR, Lang, B, Waters, P, Jones, PB, McKenna, P, et al. Disease-relevant autoantibodies in first episode schizophrenia. J Neurol 2011; 258: 686–8.CrossRefGoogle ScholarPubMed
10 Menninger, KA. Influenza and schizophrenia: an analysis of post-influenza ‘dementia praecox,’ as of 1918, and five years later. Am J Psychiatry 1926; 82: 469529.CrossRefGoogle Scholar
11 Baldridge, EB, Bessen, HA. Phencyclidine. Emerg Med Clin North Am 1990; 8: 541–50.CrossRefGoogle ScholarPubMed
12 Bujas-Bobanovic, M, Bird, DC, Robertson, HA, Dursun, SM. Blockade of phencyclidine-induced effects by a nitric oxide donor. Br J Pharmacol 2000; 130: 1005–12.CrossRefGoogle ScholarPubMed
13 Hallak, JC, Maia-de-Oliveira, JP, Abrao, J, Evora, PR, Zuardi, AW, Crippa, JAS, et al. Rapid improvement of acute schizophrenia symptoms after intravenous sodium nitroprusside: a randomized, double-blind, placebo-controlled trial. JAMA Psychiatry 2013; 70: 668–76.CrossRefGoogle ScholarPubMed
14 Kantrowitz, JT, Javitt, DC. N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia? Brain Res Bull 2010; 83: 108–21.CrossRefGoogle ScholarPubMed
15 Tsai, G, Yang, P, Chung, LC, Lange, N, Coyle, JT. D-serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 1998; 44: 1081–9.CrossRefGoogle ScholarPubMed
16 Stone, JM, Morrison, PD, Pilowsky, LS. Glutamate and dopamine dysregulation in schizophrenia – a synthesis and selective review. J Psychopharmacol 2007; 21: 440–52.CrossRefGoogle ScholarPubMed
17 Lisman, JE, Coyle, JT, Green, RW, Javitt, DC, Benes, FM, Heckers, S, et al. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci 2008; 31: 234–42.CrossRefGoogle ScholarPubMed
18 Arinuma, Y, Yanagida, T, Hirohata, S. Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 2008; 58: 1130–5.CrossRefGoogle ScholarPubMed
19 Mochizuki, Y, Mizutani, T, Isozaki, E, Ohtake, T, Takahashi, Y. Acute limbic encephalitis: a new entity? Neurosci Lett 2006; 394: 58.CrossRefGoogle ScholarPubMed
20 Iizuka, T, Sakai, F, Ide, T, Monzen, T, Yoshii, S, Iigaya, M, et al. Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal. Neurology 2008; 70: 504–11.CrossRefGoogle ScholarPubMed
21 Gonzalez-Valcarcel, J, Rosenfeld, MR, Dalmau, J. Differential diagnosis of encephalitis due to anti-NMDA receptor antibodies. Neurologia 2010; 25: 409–13.Google ScholarPubMed
22 Irani, SR, Bera, K, Waters, P, Zuliani, L, Maxwell, S, Zandi, MS, et al. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly nonparaneoplastic disorder of both sexes. Brain 2010; 133: 1655–67.CrossRefGoogle Scholar
23 Irani, SR, Vincent, A. NMDA receptor antibody encephalitis. Curr Neurol Neurosci Rep 2011; 11: 298304.CrossRefGoogle ScholarPubMed
24 Barry, H, Hardiman, O, Healy, DG, Keogan, M, Moroney, J, Molnar, PP, et al. Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis. Br J Psychiatry 2011; 199: 508–9.CrossRefGoogle ScholarPubMed
25 Dalmau, J, Tuzun, E, Wu, HY, Masjuan, J, Rossi, JE, Voloschin, A, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 2007; 61: 2536.CrossRefGoogle ScholarPubMed
26 Florance, NR, Davis, RL, Lam, C, Szperka, C, Zhou, L, Ahmad, S, et al. Anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol 2009; 66: 11–8.CrossRefGoogle ScholarPubMed
27 Pillai, SC, Gill, D, Webster, R, Howman-Giles, R, Dale, RC. Cortical hypometabolism demonstrated by PET in relapsing NMDA receptor encephalitis. Pediatr Neurol 2010; 43: 217–20.CrossRefGoogle ScholarPubMed
28 Maeder-Ingvar, M, Prior, JO, Irani, SR, Rey, V, Vincent, A, Rossetti, AO. FDG-PET hyperactivity in basal ganglia correlating with clinical course in anti-NDMA-R antibodies encephalitis. J Neurol Neurosurg Psychiatry 2011; 82: 235–6.CrossRefGoogle ScholarPubMed
29 Dale, RC, Irani, SR, Brilot, F, Pillai, S, Webster, R, Gill, D, et al. N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica. Ann Neurol 2009; 66: 704–9.CrossRefGoogle ScholarPubMed
30 Dericioglu, N, Vural, A, Acar, P, Agayeva, N, Ismailova, V, Kurne, A, et al. Antiepileptic treatment for anti-NMDA receptor encephalitis: the need for video-EEG monitoring. Epileptic Disord 2013; 2: 166–70.Google Scholar
31 Hopker, SW, Brockington, IF. Psychosis following hydatidiform mole in a patient with recurrent puerperal psychosis. Br J Psychiatry 1991; 158: 122–3.CrossRefGoogle Scholar
32 Liba, Z, Sebronova, V, Komarek, V, Sediva, A, Sedlacek, P. Prevalence and treatment of anti-NMDA receptor encephalitis. Lancet Neurol 2013; 12: 424–5.CrossRefGoogle ScholarPubMed
33 Peery, HE, Day, GS, Doja, A, Xia, C, Fritzler, MJ, Foster, WG. Anti-NMDA receptor encephalitis in children: the disorder, its diagnosis, and treatment. Handb Clin Neurol 2013; 112: 1229–33.CrossRefGoogle ScholarPubMed
34 Chapman, MR, Vause, HE. Anti-NMDA receptor encephalitis: diagnosis, psychiatric presentation, and treatment. Am J Psychiatry 2011; 168: 245–51.CrossRefGoogle ScholarPubMed
35 Fink, M, Taylor, MA. The catatonia syndrome: forgotten but not gone. Arch Gen Psychiatry 2009; 66: 1173–7.CrossRefGoogle Scholar
36 Braakman, HM, Moers-Hornikx, VM, Arts, BM, Hupperts, RM, Nicolai, J. Pearls and oysters: electroconvulsive therapy in anti-NMDA receptor encephalitis. Neurology 2011; 75: 44–6.Google Scholar
37 Watkins, CJ, Pei, Q, Newberry, NR. Differential effects of electroconvulsive shock on the glutamate receptor mRNAs, for NR2A, NR2B and mGluR5b. Brain Res Mol Brain Res 1998; 61: 108–13.CrossRefGoogle ScholarPubMed
38 Finke, C, Kopp, UA, Pruss, H, Dalmau, J, Wandinger, KP, Ploner, CJ. Cognitive deficits following anti-NMDA receptor encephalitis. J Neurol Neurosurg Psychiatry 2012; 83: 195–8.CrossRefGoogle ScholarPubMed
39 Irani, SR, Bera, K, Waters, P, Zuliani, L, Maxwell, S, Zandi, MS, et al. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly nonparaneoplastic disorder of both sexes. Brain 2010; 133: 1655–67.CrossRefGoogle Scholar
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